The Molecular Pathology Core Laboratory group works to advance molecular pathology-based, cancer research. The group addresses significant scientific and clinical research needs, and has created a central hub where researchers can interact, collaborate, and utilize novel molecular pathology technologies to translate basic science discoveries into patient care applications for cancer. Our mission comprises comprehensive pathology annotation to encompass clinical, morphological and molecular characteristics, genetic discovery in primary human tumors, with limited material and in real time, novel biomarker identification and pre-clinical trials and transitioning assays to the clinical setting.
- General Histology: Paraffin tissue processing and embedding; frozen/FFPE tissue sectioning; H&E staining; cell pellet block preparation.
- Immunohistochemistry (IHC): Chromogenic IHC (single/dual); multiplex fluorescence IHC (up to 6 markers/slide).
- TUNEL (Chromogenic/fluorescence).
- In Situ Hybridization (ISH)
- Laser Capture Microdissection (LCM): LCM training and core operated services available, plus LCM instrument use.
- Multispectral Imaging Analysis: Whole slide scanning – bright-field, fluorescence (10X, 20X, 40X); ROI image analysis – multispectral composite, segmentation, phenotyping, scoring TMA scanning and analysis.
- LCM – Arcturus XT Laser Capture Microdissection
- Cryostat – Leica CM3050 S